Anti-apartheid activist, businessman and Mandela family physician Nthato Motlana has died after a long battle with cancer, the Nelson Mandela Foundation said on Monday.

Spokesperson Sahm Venter said Motlana, one of the foundation's trustees, died on Sunday night at his Johannesburg home.

"We mourn his loss, and offer our deepest condolences and solidarity with his family and many friends at this difficult time," said Venter in a statement.

Motlana was one of the accused, with Mandela and 18 others in the 1952 Defiance Campaign Trial.

"All the accused were convicted for their role in a campaign of peaceful protests against apartheid laws. They were sentenced to nine months in jail with hard labour suspended for two years," said Venter.

Motlana was detained after the 1976 students' uprising, being a leading member of the Soweto community and vice-chair of the Black Parent's Association at the time.

Motlana was also chairperson of the Soweto Committee of Ten, one of the organisation banned by the apartheid government on 19 October, 1977 on what became known as "Black Wednesday".

Venter said in March this year Motlana attended a reunion with Mandela and other activists involved in the Defiance Campaign, Treason and Rivonia trials at the Nelson Mandela Foundation in Johannesburg.

Motlana was also an award-winning businessman. He was granted a lifetime achievement award in 2007 by the Financial Mail for his role in business and community involvement.

The award praised him as one of the "few individuals who paved the way for black business people who play in the black economic empowerment space today".

Sapa