Men can help address gender-related barriers, Deputy Health Minister Dr Molefi Sefularo said in a statement on Friday.
"We believe that the involvement of men in the fight against HIV and Aids can help to address harmful gender norms and sex stereotypes, gender-based violence and gender-related barriers," he said at a gathering in Durban's KwaMashu area.
"It also presents men with an opportunity to address the circumstances that pose a threat to their health."
Sefularo noted that the nature of the epidemic in South Africa represented "a sad accumulated legacy" of past inequalities and social norms.
He said the misrepresentation of culture accelerated behaviours and undermined positive social change.
"These social and environmental situations present themselves in manifestation such as gender inequalities, (and) violence against women and children," he said.
"Regrettably, if not addressed they will continue to be key drivers of the epidemic."
The minister was speaking as he launched a new Brother for Life campaign.
"This initiative forms part of a national multisectoral response not only to prevent new infections but also to provide leadership to the fight for equality between men and women," he said.
The campaign encouraged all South African men to open dialogue, debate and negotiate issues critical to prevent new infections.
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