A 21-year-old man is dead after a collision between his car and a provincial ambulance in the early hours of Saturday, said Netcare 911.

The driver of the ambulance was slightly injured while a passenger in the ambulance and one in the deceased's Volkswagon Jetta were each severely injured, said Netcare 911 spokesperson Chris Botha.

They have both been taken to hospital.

Botha said the accident occurred at 2am on the corner of Bartle and Stellawood. It is not yet know what caused the collision.