A 2.5 degrees Celsius rise in average world temperature above 1990 levels could cause up to two-thirds of all animal species in the Kruger National Park to become extinct, Environment Minister Marthinus van Schalkwyk warned on Monday.
A growing water scarcity in Africa could also lead to increasing numbers of so-called "environmental refugees" fleeing to better-resourced countries on the continent.
Speaking at the opening of a climate change conference at Kirstenbosch in Cape Town, Van Schalkwyk said that should global warming continue unabated, it could cause massive damage to South Africa's flagship reserve.
"An extensive report about the effects of climate change... shows that if the phenomenon continues unabated, the damage to one of South Africa's most celebrated and popular conservation and tourism areas could be shattering," Van Schalkwyk said.
This was according to an Intergovernmental Panel on Climate Change (IPCC) report, published in June this year.
Van Schalkwyk said a global response was needed to keep global warming in check.
"To avoid the worst impacts of climate change, all countries need to carry their fair share of responsibility to limit a global temperature increase to below two degrees Celsius. It will be a failure of this generation of leaders if any developed country shirks its responsibility for the problem."
South Africa itself could not continue along a business-as-usual path, without carbon constraints.
Global warming is caused by the emission of greenhouse gasses, mainly carbon dioxide released by the burning of fossil fuels.
South Africa was now faced with very difficult and important decisions relating to its own efforts to reduce and avoid emissions in order to mitigate against climate change.
Worst-case scenario
Among these was building a low carbon economy and a climate resilient society, and adapting to unavoidable climate change.
Van Schalkwyk highlighted evidence from the IPCC report, which he said underscored Africa's vulnerability to climate change. This included, among other things:
Van Schalkwyk said the longer South Africa delayed in taking action, "the greater the mitigation and adaptation costs will be".
Sapa