Several ambulances and paramedic vehicles were snowed in at Nottingham Road on the N2 on Wednesday morning, after responding to an accident, KwaZulu-Natal paramedics said.
"Paramedics were responding to a truck accident near Mooi River when the vehicles became bogged down in the heavy snow," Netcare 911 spokesperson Chris Botha said at 2.30am.
"At the moment they can't move. Disaster management and a toll concession team have gone to assist them but we will wait for daylight to see how to get in there to get them out."
Botha said a 4x4 ambulance arrived at the scene and transported an injured man to a local medical facility for further treatment.
Emergency services urged motorists to stay out of the area until the roads are cleared.
"If you do get trapped in the snow please don't leave the vehicle on foot, stay where you are until help arrives to assist you to safety," he said.
Botha said no other people were injured.
front was expected to hit the country from the south west on Friday.