Experts have predicted that the Western Leopard toad, a species endemic to the Cape, will come out for breeding within the next two weeks.
The cold and wet weather experienced in Cape Town recently has led to very little breeding season for the toads and they are seeking the warmer weather.
Motorists are asked to be on high alert at night as the toads are nocturnal creatures.
The Toad Conservation Committee's Mark Day says they are mass migraters, which means a significant portion of the population moves at one time.
He says it is important to be aware of the toads because a few cars can decimate a whole population.
Volunteers play a critical role in conservation efforts for the species. These volunteers are mainly involved during breeding season migrations, which falls between late July and early September, timed with the arrival of the first post-winter warm weather.
It is at this time when the highest number of individuals are threatened, as individuals cross busy roads to and from local breeding habitat.