The toll from a plane crash in central Mexico City, in which the interior minister died, rose to 13, the city's prosecutor said on Wednesday.

"We have 13 bodies. We are investigating to see if another woman has also died," prosecutor Miguel Angel Mancera said on Televisa news on Wednesday.

Two of the victims were female, Mancera said, adding that four had been "presumably people passing by the (crash) site."

Transport Minister Luis Tellez said the crash in Tuesday evening rush hour traffic had been an accident, amid speculation that it had been caused by a deliberate attack on two key players in the government's crackdown on drug trafficking.

"There have been no signs that permit another hypothesis than an accident, but investigations will explore all possibilities," Tellez said in a statement.

The deaths of Interior Minister Juan Camilo Mourino and security advisor Jose Luis Santiago Vasconcelos were a massive blow to the government's anti-drug strategy.

Mourino had led a government campaign against mounting drug-related violence — in which some 4000 have died so far this year — including the deployment of some 36 000 troops across the country.

AFP